Genetic aberrations on the short arm of chromosome 8 (8p) in tongue carcinomas
Murano Akiyuki, Ono Kanae, Koike Hirofumi, Endo Yosuke, Shimada Ken, Kawasaki Kenshi, Nomura Hitomi, Shiiba Masashi, Uzawa Katsuhiro, Tanzawa Hideki,
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( Murano Akiyuki ) - Japan Chiba University Hospital Department of Dentistry and Oral Surgery
( Ono Kanae ) - Japan Chiba University Hospital Department of Dentistry and Oral Surgery
( Koike Hirofumi ) - Japan Chiba University Hospital Department of Dentistry and Oral Surgery
( Endo Yosuke ) - Japan Chiba University Hospital Department of Dentistry and Oral Surgery
( Shimada Ken ) - Japan Chiba University Hospital Department of Dentistry and Oral Surgery
( Kawasaki Kenshi ) - Japan Chiba University Hospital Department of Dentistry and Oral Surgery
( Nomura Hitomi ) - Japan Chiba University Hospital Department of Dentistry and Oral Surgery
( Shiiba Masashi ) - Japan Chiba University Hospital Department of Dentistry and Oral Surgery
( Uzawa Katsuhiro ) - Japan Chiba University Hospital Department of Dentistry and Oral Surgery
( Tanzawa Hideki ) - Japan Chiba University Hospital Department of Dentistry and Oral Surgery
KMID : 0355620120380020121
Abstract
Aberrations on the short arm of chromosome 8 (8p) are frequently observed in several human cancers. In this study, 20 squamous cell carcinoma (SCC) specimens from the tongue were examined in order to evaluate the role of 8p in SCC of the tongue. Microsatellite analysis using 14 markers demonstrated two commonly deleted regions (CDRs) on 8p. Reverse transcription-polymerase chain reaction (RT-PCR) revealed frequent downregulation of the FEZ1 gene, mapped to 8p22, and frequent over-expression of the cathepsin B gene, mapped to 8p-21-22. These results suggested that genetic aberrations are involved in the development of SCC of the tongue. However, no significant relationship was observed to be established between the genetic alterations and clinicopathological features. Thus, further investigation is necessary in order to clarify the clinical role of 8p in carcinoma of the tongue.
키워드
Loss of heterozygosity; Tongue carcinoma; FEZ1 gene; Cathepsin B gene
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